Human Laboratory Research to Inform Precision Regulation of E-cigarettes Across Populations
This project, known as TCORS Project 4, will identify dimensions of e-cigarette product diversity that put young adult never-smokers at risk of using e-cigarettes, yet do not deter middle/older adult smokers from adopting and potentially switching to e-cigarettes. In two studies, subjects will self-administer e-cigarette products varied according to three dimensions: flavor (e.g., sweet vs. menthol vs. tobacco); propylene glycol/vegetable glycerin ratio (e.g., 20:80 vs. 40:60 vs. 60:40 vs. 80:20); and packaging design (e-liquid characterizing flavor label [e.g., “peach”] vs. youth-oriented non-characterizing flavor [e.g., “gummy heaven”] vs. non-characterizing flavor + cartoon).
Aim 1: To determine which dimensions of e-cigarette product diversity differentially affect product appeal in never-smoking young adult e-cigarette users and middle-aged/older adult smokers with an interest in, but no significant experience with, e-cigarettes.
Aim 2: To determine which dimensions of e-cigarette product diversity differentially affect abuse liability in never-smoking young adult e-cigarette users and ability to resist smoking in middle-aged/older adult smokers with an interest in, but no significant experience with, e-cigarettes.
Aim 3: To examine sex differences in the effects of product diversity on appeal, abuse liability, and ability to resist smoking by testing sex and product dimension interactions.
Effects of Ice Flavors and Nicotine on E-Cigarette Product Appeal and Likelihood of Future Use in Adults
To test the hypothesis that there will be a main effect of flavor on appeal and intention to use, that there will be an interaction between ice flavor status and nicotine concentration, and to determine if there are effects of tobacco product user status.
Examining Risk Beliefs and IQOS Use Among Adults
To assess the effect of provision of IQOS, evaluate shifts in product perceptions and examine the acute changes via EMA/mobile spirometry in pulmonary functioning upon switching from combustible cigarettes to IQOS.
Evaluating the Influence of Local Flavored E-cigarette Sales Restrictions on E-cigarette and Other Tobacco Use Outcomes Among Vulnerable Populations
To examine the influence of FESRs on e-cigarette use, other tobacco use, and tobacco purchasing location among the historically targeted vulnerable populations