Adam de Smith, PhD
Assistant Professor of Clinical
Health Equity Interests
Understanding the causes of childhood leukemia, with a special focus on high risk groups including Hispanic/Latinos and children with Down syndrome
Adam de Smith is an Assistant Professor in the USC Center for Genetic Epidemiology in the Department of Preventive Medicine, and is a member of the USC Norris Comprehensive Cancer Center. He is a genetic epidemiologist with a research focus on identifying the causes of acute lymphoblastic leukemia (ALL), the most common childhood cancer. Dr. de Smith leads studies investigating the role of common and rare genetic variants in ALL etiology, with a particular interest in elucidating the increased ALL risk in Latinos. He also leads a study of leukemia in children with Down syndrome, the International Study of Down Syndrome Acute Leukemia (IS-DSAL), investigating genetic and epigenetic variation associated with risk of DS-ALL. In addition, Dr. de Smith utilizes whole genome sequencing of tumors to examine potential causative agents, i.e. DNA mutational signatures as molecular footprints of environmental exposures.
- Ethnic Disparities
- Risk Factors
- Molecular Epidemiology
- Cancer Epidemiology
- Epidemiological Factors
- Genomic Data Sciences
Localized variation in ancestral admixture identifies pilocytic astrocytoma risk loci among Latino children.
PLoS Genet. 2022 Sep;18(9):e1010388. doi: 10.1371/journal.pgen.1010388. Epub 2022 Sep 7. PubMed PMID: 36070312; PubMed Central PMCID: PMC9484652.
Exploring the genetic and epigenetic origins of juvenile myelomonocytic leukemia using newborn screening samples.
Leukemia. 2022 Jan;36(1):279-282. doi: 10.1038/s41375-021-01331-0. Epub 2021 Jun 28. PubMed PMID: 34183765; PubMed Central PMCID: PMC8720242.
Genome-wide trans-ethnic meta-analysis identifies novel susceptibility loci for childhood acute lymphoblastic leukemia.
Leukemia. 2022 Mar;36(3):865-868. doi: 10.1038/s41375-021-01465-1. Epub 2021 Nov 8. PubMed PMID: 34750507;
Development of a Droplet Digital™ PCR DNA methylation detection and quantification assay of prenatal tobacco exposure.
Biotechniques. 2022 Mar 8;. doi: 10.2144/btn-2021-0099. Epub 2022 Mar 8. PubMed PMID: 35255733;
Clinical characteristics of cytomegalovirus-positive pediatric acute lymphoblastic leukemia at diagnosis.
Am J Hematol. 2022 Mar 14;. doi: 10.1002/ajh.26528. Epub 2022 Mar 14. PubMed PMID: 35285969;