Adam de Smith, PhD
Assistant Professor of Population and Public Health Sciences
Health Equity Interests
Understanding the causes of childhood leukemia, with a special focus on high risk groups including Hispanic/Latinos and children with Down syndrome
Adam de Smith is an Assistant Professor in the USC Center for Genetic Epidemiology in the Department of Preventive Medicine, and is a member of the USC Norris Comprehensive Cancer Center. He is a genetic epidemiologist with a research focus on identifying the causes of acute lymphoblastic leukemia (ALL), the most common childhood cancer. Dr. de Smith leads studies investigating the role of common and rare genetic variants in ALL etiology, with a particular interest in elucidating the increased ALL risk in Latinos. He also leads a study of leukemia in children with Down syndrome, the International Study of Down Syndrome Acute Leukemia (IS-DSAL), investigating genetic and epigenetic variation associated with risk of DS-ALL. In addition, Dr. de Smith utilizes whole genome sequencing of tumors to examine potential causative agents, i.e. DNA mutational signatures as molecular footprints of environmental exposures.
- Ethnic Disparities
- Risk Factors
- Molecular Epidemiology
- Cancer Epidemiology
- Epidemiological Factors
- Genomic Data Sciences
Multi-ancestry genome-wide association study of 4,069 children with glioma identifies 9p21.3 risk locus.
Neuro Oncol. 2023 Feb 22;. doi: 10.1093/neuonc/noad042. Epub 2023 Feb 22. PubMed PMID: 36810956;
Meta-Analysis of DNA Methylation Datasets Shows Aberrant DNA Methylation of Thyroid Development or Function Genes in Down Syndrome.
Thyroid. 2023 Jan;33(1):53-62. doi: 10.1089/thy.2022.0320. Epub 2022 Dec 20. PubMed PMID: 36326208;
Accelerated epigenetic aging in newborns with Down syndrome.
Aging Cell. 2022 Jul;21(7):e13652. doi: 10.1111/acel.13652. Epub 2022 Jun 6. PubMed PMID: 35661546; PubMed Central PMCID: PMC9282838.
Development of a Droplet Digital™ PCR DNA methylation detection and quantification assay of prenatal tobacco exposure.
Biotechniques. 2022 Mar 8;. doi: 10.2144/btn-2021-0099. Epub 2022 Mar 8. PubMed PMID: 35255733;
Clinical characteristics of cytomegalovirus-positive pediatric acute lymphoblastic leukemia at diagnosis.
Am J Hematol. 2022 Mar 14;. doi: 10.1002/ajh.26528. Epub 2022 Mar 14. PubMed PMID: 35285969;