Joshua Millstein, PhD
Associate Professor of Research Population and Public Health Sciences
Dr. Millstein's research is focused on developing and applying statistical methods to address the many challenges of high dimensional data, particularly in multi-omic population-based studies of the genome, epigenome, transcriptome, microbiome, etc., in the context of pathogenesis of complex diseases such as cancer. With massive amounts of data collected in typical studies due to these advancing technologies, it has become increasingly important to have computational tools able to sift through all the information to separate the signal of interest from the noise. Specific areas of methods development include, causal mediation (CIT), dimensionality reduction, causal networks, false discovery rates (FDR), and epistasis/statistical interactions.
Association of improved air quality with lower dementia risk in older women.
Proc Natl Acad Sci U S A. 2022 Jan 11;119(2). doi: 10.1073/pnas.2107833119. PubMed PMID: 34983871; PubMed Central PMCID: PMC8764698.
fdrci: FDR confidence interval selection and adjustment for large-scale hypothesis testing.
Bioinform Adv. 2022;2(1):vbac047. doi: 10.1093/bioadv/vbac047. Epub 2022 Jun 13. PubMed PMID: 35747247; PubMed Central PMCID: PMC9210923.
Genetic variants involved in the cGAS-STING pathway predict outcome in patients with metastatic colorectal cancer: Data from FIRE-3 and TRIBE trials.
Eur J Cancer. 2022 Jun 21;172:22-30. doi: 10.1016/j.ejca.2022.05.016. Epub 2022 Jun 21. PubMed PMID: 35749909;
Ambient air pollution exposure and increasing depressive symptoms in older women: The mediating role of the prefrontal cortex and insula.
Sci Total Environ. 2022 Jun 1;823:153642. doi: 10.1016/j.scitotenv.2022.153642. Epub 2022 Feb 3. PubMed PMID: 35122843; PubMed Central PMCID: PMC8983488.
Germline Polymorphisms in Genes Involved in the Antioxidant System Predict the Efficacy of Cetuximab in Metastatic Colorectal Cancer Patients Enrolled in FIRE-3 Trial.
Clin Colorectal Cancer. 2022 May 23;. doi: 10.1016/j.clcc.2022.05.005. Epub 2022 May 23. PubMed PMID: 35710481;