Jaana Hartiala, PhD
Assistant Professor of Clinical Population and Public Health Sciences
Biography
Jaana A. Hartiala, Ph.D., is an Assistant Professor of Clinical Preventive Medicine in the Department of Preventive Medicine at the University of Southern California. She earned her doctorate in Molecular Epidemiology from the University of Southern California. Dr. Hartiala received her post-doctoral training in Applied Statistical Genetics at the USC Keck School of Medicine, where she studied genome-wide associations of metabolite levels and cardiovascular disease. Dr. Hartiala's research interests include systems genetics and computational biology approaches to identify genes and pathways for cardiovascular and pulmonary diseases; identification of environmental exposures that modulate susceptibility to cardiopulmonary diseases using epidemiological approaches; and study genome-wide gene-environment interactions for disease outcome and associated biomarkers. Dr. Hartiala's more recent work include identifying a sex-specific genetic variant in the CPS1 gene that raises glycine levels and protects against cardiovascular disease among women. In another project, she showed that ambient air pollution is associated with the severity of coronary atherosclerosis and incident myocardial infarction among cardiac patients. Her current projects involve integrating large scale genetic, gene expression and metabolomic data to understand susceptibility to atherosclerosis and asthma.
Publications
Associations of Polymorphisms in the Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1 Alpha Gene With Subsequent Coronary Heart Disease: An Individual-Level Meta-Analysis.
Front Physiol. 2022;13:909870. doi: 10.3389/fphys.2022.909870. Epub 2022 Jun 23. PubMed PMID: 35812313; PubMed Central PMCID: PMC9260705.
Clinical Intervention to Reduce Dietary Sugar Does Not Affect Liver Fat in Latino Youth, Regardless of PNPLA3 Genotype: A Randomized Controlled Trial.
J Nutr. 2022 Jul 6;152(7):1655-1665. doi: 10.1093/jn/nxac046. PubMed PMID: 35218194; PubMed Central PMCID: PMC9258557.
Effect of menopausal hormone therapy on methylation levels in early and late postmenopausal women.
Clin Epigenetics. 2022 Jul 18;14(1):90. doi: 10.1186/s13148-022-01311-w. Epub 2022 Jul 18. PubMed PMID: 35850911; PubMed Central PMCID: PMC9295504.
Gene-Environment Interactions for Cardiovascular Disease.
Curr Atheroscler Rep. 2021 Oct 14;23(12):75. doi: 10.1007/s11883-021-00974-9. Epub 2021 Oct 14. PubMed PMID: 34648097; PubMed Central PMCID: PMC8903169.
Association of serum HDL cholesterol and apolipoprotein A1 levels with risk of severe SARS-CoV-2 infection.
J Lipid Res. 2021 Mar 2;:100061. doi: 10.1016/j.jlr.2021.100061. Epub 2021 Mar 2. PubMed PMID: 33667465; PubMed Central PMCID: PMC7923911.